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Not surprisingly, this gene and many of its regulators are implicated in metabolic diseases, including obesity and diabetes ( Figure 1 Mutant p53 Positively Regulates Warburg Metabolism (Aerobic Glycolysis) In contrast to the function of WT p53, mutant p53 in tumor cells favors aerobic glycolysis, in part by enhancing the trafficking of the glucose transporter GLUT1 to the plasma membrane, hence increasing glucose import ( SCO2 and GLS2 and the increased levels of GLUT1 and GLUT4 favor aerobic glycolysis over oxidative phosphorylation

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Preliminary results (Friedman, Cabrales, Davies unpublished results) indicate that systemic efficacy (vascular and inflammatory response) can be achieved via topical delivery of both NO and curcumin-releasing nanoparticles